Chemists from the University of Warwick and Monash University have discovered a powerful new antibiotic called pre-methylenomycin C lactone, found as an intermediate compound in the production of methylenomycin A[^1]. This molecule shows remarkable potency against drug-resistant bacteria, demonstrating over 100 times greater activity against Gram-positive pathogens compared to methylenomycin A[^2].

The compound proves particularly effective against Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE), with no observed resistance development in Enterococcus faecium under conditions where vancomycin resistance typically emerges[^1].

“Methylenomycin A was originally discovered 50 years ago and while it has been synthesized several times, no-one appears to have tested the synthetic intermediates for antimicrobial activity!” said Professor Greg Challis[^2]. The team identified the compound by deleting specific genes in Streptomyces coelicolor, a well-studied soil bacterium[^1].

The researchers have developed a scalable synthetic route for producing pre-methylenomycin C lactone, positioning it for further development as a potential treatment against antimicrobial-resistant infections[^1].

[^1]: Medical Dialogues - Scientists discover hidden antibiotic 100 times stronger against superbugs

[^2]: University of Warwick - New antibiotic for drug-resistant bacteria found hiding in plain sight

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(pubs.acs.org)