What school of cuisine is the chowder?

Showwdair!

Ah yes, like The Tale of Eric and the Dread Gazebo. A classic.

Not one crime, at least two: belonging to a secret society, and having an unregistered mutant power. Except some secret societies might actually be sponsored by the state— not that the players know that. And you can register your mutant power, except that this will make you a targeted minority subject to massive discrimination, not to mention being forced to use your power in service— and your own power might kill you, and you don’t really know how to use it fully, and being forced to use it also means being put on the front lines of deadly combat…

But that’s not what makes the adversarial play in paranoia so great. It’s that everyone has a different true objective that they are following in secret, while ostensively all being on the same team. That’s what I mean by “there are winners and losers in this game”. You can objectively determine who succeeded and who failed, and a good mission will make those secret missions mutually exclusive. It’s great fun!

It’s like in d&d when you get the asshole player who really just wants to steal from the rest of the party and not get caught, except everyone is in on it and everyone is trying to do something different to everyone else, to very different degrees, and everyone expects to be betrayed at all times, and often is— except you get extra lives so you can keep playing anyway… and then you get to laugh about it together at the end! It’s great!

That happened to my buddy Eric

If Detect Evil and Good detects creature type then sure, maybe Detect Magic detects chowder.

No magic. No curse. Just your average every day poison.

The only idea I even have for such a campaign is one where all the BBGs are dopplegangers of the party and the players are trying to defeat me, playing as their dopplegangers.

I would only be able to do what the players themselves can do. So it becomes a test of who understands the build better. The player or the DM.