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  3. Tattoo Ink Moves Through the Body, Killing Immune Cells and Weakening Vaccine Response

Tattoo Ink Moves Through the Body, Killing Immune Cells and Weakening Vaccine Response

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  • KingK King

    Study

    The researchers discovered that once a tattoo is made, the ink rapidly travels through the lymphatic system and, within hours, accumulates in large quantities in the lymph nodes — key organs of the body’s defense system. Inside these nodes, immune cells called macrophages actively capture all types of pigment. This ink uptake triggers an inflammatory response with two phases: an acute phase lasting about two days after tattooing, followed by a chronic phase that can persist for years. The chronic phase is particularly concerning because it weakens the immune system, potentially increasing the susceptibility to infections and cancer. The study also showed that macrophages cannot break down the ink like they would other pathogens, wich causes them to die, especially with red and black inks, suggesting these colors may be more toxic. As a result, ink remains trapped in the lymph nodes in a continuous cycle of capture and cell death, gradually affecting the immune system’s defensive capacity.

    The study found that tattooed mice produced significantly lower levels of antibodies after vaccination. This effect is likely due to the impaired function of immune cells that remain associated with tattoo ink for long periods. Similarly, human immune cells previously exposed to ink also showed a weakened response to vaccination.

    W This user is from outside of this forum
    W This user is from outside of this forum
    wubwub@lemmy.zip
    wrote on last edited by
    #10

    The anti tatto crowd licking their lips over this one.

    Ji Fu (Domestic Terrorist)F underpantsweevil@lemmy.worldU 2 Replies Last reply
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    • O onomatopoeia@lemmy.cafe

      “Human immune cells”, not cells in humans.

      That’s not to say this doesn’t happen in humans, it very well may. It’s intriguing research, but it’s still only demonstrated in mice. Important to always keep that in mind until we get better information (which this research is at least leading us to).

      Lots of stuff happens in mice (or pigs, or a petri dish) and we find doesn’t replicate to homo sapiens.

      F This user is from outside of this forum
      F This user is from outside of this forum
      flexibletoast@lemmy.world
      wrote on last edited by flexibletoast@lemmy.world
      #11

      It’s also important to keep on mind that the burden of proof is on something to prove it is safe, not that something is unsafe. It happening to human cells in mice would have me assume it happens to human cells in humans until proven otherwise (that’s the null hypothesis in this situation). But also I don’t have a tattoo or any interest in getting one so I’m not too bothered by this.

      adaA 1 Reply Last reply
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      • W wubwub@lemmy.zip

        The anti tatto crowd licking their lips over this one.

        Ji Fu (Domestic Terrorist)F This user is from outside of this forum
        Ji Fu (Domestic Terrorist)F This user is from outside of this forum
        Ji Fu (Domestic Terrorist)
        wrote on last edited by
        #12
        @Wubwub anti tattoo crowd? Like fundamentalist Baptists?
        T R 2 Replies Last reply
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        • S salacious_coaster@infosec.pub

          Well, then. That could explain a lot about why I always feel like I’m dying.

          proper@lemmy.worldP This user is from outside of this forum
          proper@lemmy.worldP This user is from outside of this forum
          proper@lemmy.world
          wrote on last edited by
          #13

          are you the puzzle man?

          1 Reply Last reply
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          • A answersplease77@lemmy.world

            followed by a chronic phase that can persist for years.

            how many years? am I doomed for life because what I did to my body when I was 18 😞

            D This user is from outside of this forum
            D This user is from outside of this forum
            darkcloud@lemmy.world
            wrote on last edited by
            #14

            I think if these effects were universal and as serious as the paper makes out, we’d have noticed them waaay sooner.

            S J 2 Replies Last reply
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            • F flexibletoast@lemmy.world

              It’s also important to keep on mind that the burden of proof is on something to prove it is safe, not that something is unsafe. It happening to human cells in mice would have me assume it happens to human cells in humans until proven otherwise (that’s the null hypothesis in this situation). But also I don’t have a tattoo or any interest in getting one so I’m not too bothered by this.

              adaA This user is from outside of this forum
              adaA This user is from outside of this forum
              ada
              wrote on last edited by
              #15

              Humans have been tattooing each other for over 5000 years. I would argue that it’s not really a case of “they need to be proven to be safe”. That ship has sailed. If they are unsafe, we should know, but I think the burden of proof has definitely shifted on tattoos given their extensive history without obvious negative repercussion

              P 1 Reply Last reply
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              • S salacious_coaster@infosec.pub

                Well, then. That could explain a lot about why I always feel like I’m dying.

                Björn TantauB This user is from outside of this forum
                Björn TantauB This user is from outside of this forum
                Björn Tantau
                wrote on last edited by
                #16

                I have the opposite problem, my immune system is in overdrive. I should get a tattoo to reign it in.

                T 1 Reply Last reply
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                • Ji Fu (Domestic Terrorist)F Ji Fu (Domestic Terrorist)
                  @Wubwub anti tattoo crowd? Like fundamentalist Baptists?
                  T This user is from outside of this forum
                  T This user is from outside of this forum
                  Thymos
                  wrote on last edited by
                  #17

                  I suppose I would be in that crowd. I’m an atheist, but I think the whole tattooing thing is kinda stupid. To each their own of course, I don’t care if anyone gets a tattoo, but the culture around it annoys me and I think it’s a waste of one’s body. I do like some of the art styles, but why not just print it on a shirt and wear it?

                  That being said, I think it’s petty bad if it turns out the ink causes a higher risk of disease. Like with cigarettes in the past people weren’t informed about the consequences before making their choices. That sucks and I don’t wish it on anyone.

                  Øπ3ŕO L 2 Replies Last reply
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                  • T Thymos

                    I suppose I would be in that crowd. I’m an atheist, but I think the whole tattooing thing is kinda stupid. To each their own of course, I don’t care if anyone gets a tattoo, but the culture around it annoys me and I think it’s a waste of one’s body. I do like some of the art styles, but why not just print it on a shirt and wear it?

                    That being said, I think it’s petty bad if it turns out the ink causes a higher risk of disease. Like with cigarettes in the past people weren’t informed about the consequences before making their choices. That sucks and I don’t wish it on anyone.

                    Øπ3ŕO This user is from outside of this forum
                    Øπ3ŕO This user is from outside of this forum
                    Øπ3ŕ
                    wrote on last edited by
                    #18

                    It’s good that you’ve expressed misconception as the source of this opinion, and admitted to your lack of understanding. The rest of the work could fall in nicely, if you put the effort forth. I’ll give ya one for free: “the culture around it” isn’t some singular entity, but a varied and colorful amalgam of countless inspirations, backgrounds, beliefs, reasons, etc., and the only thing that oversimplifying does here is stunt your personal growth.

                    You got this. 🤘🏼

                    T 1 Reply Last reply
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                    • KingK King

                      Study

                      The researchers discovered that once a tattoo is made, the ink rapidly travels through the lymphatic system and, within hours, accumulates in large quantities in the lymph nodes — key organs of the body’s defense system. Inside these nodes, immune cells called macrophages actively capture all types of pigment. This ink uptake triggers an inflammatory response with two phases: an acute phase lasting about two days after tattooing, followed by a chronic phase that can persist for years. The chronic phase is particularly concerning because it weakens the immune system, potentially increasing the susceptibility to infections and cancer. The study also showed that macrophages cannot break down the ink like they would other pathogens, wich causes them to die, especially with red and black inks, suggesting these colors may be more toxic. As a result, ink remains trapped in the lymph nodes in a continuous cycle of capture and cell death, gradually affecting the immune system’s defensive capacity.

                      The study found that tattooed mice produced significantly lower levels of antibodies after vaccination. This effect is likely due to the impaired function of immune cells that remain associated with tattoo ink for long periods. Similarly, human immune cells previously exposed to ink also showed a weakened response to vaccination.

                      F This user is from outside of this forum
                      F This user is from outside of this forum
                      fandangalo@lemmy.world
                      wrote on last edited by
                      #19

                      I don’t want to use AI to generate the sick, tattooed mice in this story, but I bet they’re pretty rad. (Animal testing, less so, jokes aside)

                      1 Reply Last reply
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                      • D darkcloud@lemmy.world

                        I think if these effects were universal and as serious as the paper makes out, we’d have noticed them waaay sooner.

                        S This user is from outside of this forum
                        S This user is from outside of this forum
                        scytale
                        wrote on last edited by
                        #20

                        To be fair, it’s possible it has been a significant factor to weakend immune systems all along; it was just now that the connection/link with tattoo ink was identified. Not a scientist obviously, just spitballing.

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                        • Ji Fu (Domestic Terrorist)F Ji Fu (Domestic Terrorist)
                          @Wubwub anti tattoo crowd? Like fundamentalist Baptists?
                          R This user is from outside of this forum
                          R This user is from outside of this forum
                          rabber@lemmy.ca
                          wrote on last edited by rabber@lemmy.ca
                          #21

                          I’m a pantheist and think that tattoos are just another form of self harm

                          My gf has tattoos and I don’t mind them but I wish she wouldn’t get any more. Impossible to find a girl without tattoos who would date me anyway lol I tend to attract the alternative crowd and basically everyone I’d be into has them so it is what it is

                          1 Reply Last reply
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                          • W wubwub@lemmy.zip

                            The anti tatto crowd licking their lips over this one.

                            underpantsweevil@lemmy.worldU This user is from outside of this forum
                            underpantsweevil@lemmy.worldU This user is from outside of this forum
                            underpantsweevil@lemmy.world
                            wrote on last edited by
                            #22

                            It’s just tiresome to hear these hyperventilating articles without any real measure of the degree of risk or long term consequences.

                            W F 2 Replies Last reply
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                            • underpantsweevil@lemmy.worldU underpantsweevil@lemmy.world

                              It’s just tiresome to hear these hyperventilating articles without any real measure of the degree of risk or long term consequences.

                              W This user is from outside of this forum
                              W This user is from outside of this forum
                              wubwub@lemmy.zip
                              wrote on last edited by
                              #23

                              Exactly, I understand the concept of the harm they are talking about but they don’t really give much exact examples of the degree of harm its a total nothing burger of an article

                              1 Reply Last reply
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                              • KingK King

                                Study

                                The researchers discovered that once a tattoo is made, the ink rapidly travels through the lymphatic system and, within hours, accumulates in large quantities in the lymph nodes — key organs of the body’s defense system. Inside these nodes, immune cells called macrophages actively capture all types of pigment. This ink uptake triggers an inflammatory response with two phases: an acute phase lasting about two days after tattooing, followed by a chronic phase that can persist for years. The chronic phase is particularly concerning because it weakens the immune system, potentially increasing the susceptibility to infections and cancer. The study also showed that macrophages cannot break down the ink like they would other pathogens, wich causes them to die, especially with red and black inks, suggesting these colors may be more toxic. As a result, ink remains trapped in the lymph nodes in a continuous cycle of capture and cell death, gradually affecting the immune system’s defensive capacity.

                                The study found that tattooed mice produced significantly lower levels of antibodies after vaccination. This effect is likely due to the impaired function of immune cells that remain associated with tattoo ink for long periods. Similarly, human immune cells previously exposed to ink also showed a weakened response to vaccination.

                                arctanthropeA This user is from outside of this forum
                                arctanthropeA This user is from outside of this forum
                                arctanthrope
                                wrote on last edited by
                                #24

                                would it be possible to solve this problem by making different inks? or would any ink that doesn’t have this problem just inherently be non-permanent

                                P 1 Reply Last reply
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                                • V vatlark@lemmy.world

                                  In the study the longest they waited after tattooing the mouse before giving the vaccine was 2 months.

                                  They made some connections with people that had tattoos for a much longer time. But I can’t tell how meaningful those connections are.

                                  This is well outside of my field.

                                  Edit:

                                  Also, it sounds like the tattooed mice were less responsive to the covid vaccine but more responsive to the Influenza vaccine.

                                  S This user is from outside of this forum
                                  S This user is from outside of this forum
                                  sendmephotos@lemmy.world
                                  wrote on last edited by
                                  #25

                                  … This is the internet. You can always be like the rest and pretend you know everything and are multi discaplined, instead of taking the proper, less fun, honest route.

                                  G F 2 Replies Last reply
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                                  • T thejoker954@lemmy.world

                                    The study found that tattooed mice produced significantly lower levels of antibodies after vaccination. This effect is likely due to the impaired function of immune cells that remain associated with tattoo ink for long periods. Similarly, human immune cells previously exposed to ink also showed a weakened response to vaccination

                                    G This user is from outside of this forum
                                    G This user is from outside of this forum
                                    grue@lemmy.world
                                    wrote on last edited by
                                    #26

                                    I suspect the effect might be less significant in humans (not human cells, whole humans) because of the square-cube law.

                                    1 Reply Last reply
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                                    • D darkcloud@lemmy.world

                                      I think if these effects were universal and as serious as the paper makes out, we’d have noticed them waaay sooner.

                                      J This user is from outside of this forum
                                      J This user is from outside of this forum
                                      jacksilver@lemmy.world
                                      wrote on last edited by
                                      #27

                                      And yet things like asbestos, lead, and smoking all took way longer than you’d expect (given they were a lot more universal).

                                      confused_emus@lemmy.dbzer0.comC A 2 Replies Last reply
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                                      • KingK King

                                        Study

                                        The researchers discovered that once a tattoo is made, the ink rapidly travels through the lymphatic system and, within hours, accumulates in large quantities in the lymph nodes — key organs of the body’s defense system. Inside these nodes, immune cells called macrophages actively capture all types of pigment. This ink uptake triggers an inflammatory response with two phases: an acute phase lasting about two days after tattooing, followed by a chronic phase that can persist for years. The chronic phase is particularly concerning because it weakens the immune system, potentially increasing the susceptibility to infections and cancer. The study also showed that macrophages cannot break down the ink like they would other pathogens, wich causes them to die, especially with red and black inks, suggesting these colors may be more toxic. As a result, ink remains trapped in the lymph nodes in a continuous cycle of capture and cell death, gradually affecting the immune system’s defensive capacity.

                                        The study found that tattooed mice produced significantly lower levels of antibodies after vaccination. This effect is likely due to the impaired function of immune cells that remain associated with tattoo ink for long periods. Similarly, human immune cells previously exposed to ink also showed a weakened response to vaccination.

                                        P03 LockeP This user is from outside of this forum
                                        P03 LockeP This user is from outside of this forum
                                        P03 Locke
                                        wrote on last edited by p03locke@lemmy.dbzer0.com
                                        #28

                                        There are far too many humans with tattoos that could have been researched extensively, but they chose mice. Mice do not have the same kind of skin density as humans, and I doubt a tattoo artist or researcher would have the talent to tattoo a mouse’s skin.

                                        There’s just so many things wrong with using mice in this study. So many bad ratios with the size of the animal. I mean, for fuck’s sake, tattoo artists already practice on pig skin. Pigs would have been a better analogue, but honestly, they should have picked the millions of humans who were already tattooing themselves.

                                        Of course, if they did that, they wouldn’t get the same result and be able to push this sensationalist science news title, now would they? Except, in this case, we’ve gone from research paper to straight to sensationalist news title in one step! Just let the institute PR department push the narrative for you, without having to wait for that pesky news cycle to crawl through the telephone game.

                                        etherwhack@lemmy.worldE H bonenodeB V L 6 Replies Last reply
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                                        • KingK King

                                          Study

                                          The researchers discovered that once a tattoo is made, the ink rapidly travels through the lymphatic system and, within hours, accumulates in large quantities in the lymph nodes — key organs of the body’s defense system. Inside these nodes, immune cells called macrophages actively capture all types of pigment. This ink uptake triggers an inflammatory response with two phases: an acute phase lasting about two days after tattooing, followed by a chronic phase that can persist for years. The chronic phase is particularly concerning because it weakens the immune system, potentially increasing the susceptibility to infections and cancer. The study also showed that macrophages cannot break down the ink like they would other pathogens, wich causes them to die, especially with red and black inks, suggesting these colors may be more toxic. As a result, ink remains trapped in the lymph nodes in a continuous cycle of capture and cell death, gradually affecting the immune system’s defensive capacity.

                                          The study found that tattooed mice produced significantly lower levels of antibodies after vaccination. This effect is likely due to the impaired function of immune cells that remain associated with tattoo ink for long periods. Similarly, human immune cells previously exposed to ink also showed a weakened response to vaccination.

                                          PavidusP This user is from outside of this forum
                                          PavidusP This user is from outside of this forum
                                          Pavidus
                                          wrote on last edited by
                                          #29

                                          Ephemeral Remi should be dead by now.

                                          1 Reply Last reply
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