Splenda doesn’t contain erythritol. That makes that whole article suspect.

Artificial Sweetener Erythritol Linked to Brain Vascular Cell Dysfunction

Learn how erythritol affects brain blood vessels - keep reading for essential clinical insights and implications for sweetener use.

European Medical Journal (www.emjreviews.com)

Source that actually names the thing in its title.

Unfortunately it’s of course barely readable for laypeople. So is there a safe upper limit? Like if I put a teaspoon of it in my cup of coffee, am I destroying my brain?

Cells were treated with 6 mM erythritol, replicating the concentration found in a typical serving of an artificially sweetened drink, for three hours.

What’s “mM”?

Millimolar https://en.wikipedia.org/wiki/Molar_concentration?wprov=sfla1

Ah. I remember that from desperately trying to wrap my head around it in Chemistry class. Thank you, it’s impossible to search for.

Yep. Erythiol has a molecular weight of 122 g/mol, so 6 mM is the same as 0.732 g/liter.

It should be noted that the cells were exposed to the full concentration in the drinks, so the concentration they encountered is much higher than it is when it has been diluted by all the water in our bodies after we drink it.

Not for diabetics

Splenda the brand certainly sells erythritol; it’s not their main product

Edit: Here’s the one from my cupboard

ProZD - clickbait/YOU WON’T BELIEVE meme

I never click on clickbait. I refuse to support anyone who engages in that practice.

Skimming the article is the same as reading it in full - they just want to place their cookies, and clicking the link is enough to do that if you don’t go through all the settings including turning off all the “legitimate interest” options - and that is often a pain to do.

I have an extension that automatically does cookies for me

Ingredients:

“Maltodextrin, Monk Fruit Extract”

No mention of erythritol.

Splenda Monk Fruit Sweetener Pouch | Zero Calorie Sweetener. Tastes Like Sugar

Our Splenda Monk Fruit Sweetener Pouch is made with monk fruit extract and is zero calories! Enjoy sweetness that satisfies, without the calories.

Splenda® (www.splenda.com)

Not all monk fruit sweeteners contain erythritol.

Does All Monk Fruit Have Erythritol? | Sweet Clarity

Not all monk fruit sweeteners contain erythritol; some are pure monk fruit extract without additives.

(wellwisp.com)

You’d think they’d list that on their website.

So do I, but it doesn’t turn off the legitimate interest on a lot of sites. I suspect that the cookie corps are working hard to circumvent it.

Apparently they do https://www.splenda.com/product/splenda-monk-fruit-sweetener-jar/

Except for the numerous other artificial sweeteners that have been found to also have negative effects. This has been a trend, and I think that’s what they meant by that statement

Their research says nothing about sweeteners that weren’t part of their study.

I mean, this was brain cells directly exposed to it in concentrations far higher than would occur in a human body after metabolism with no secondary carbohydrates that would likely come with eating said food (units you like eating spoonfuls of pure Splenda I suppose).

I think brain cells wouldn’t do well exposed directly to many things, like too much oxygen, either.

So I’d say this study should be taken with a grain of salt sugar

Correct. However, it ‘adds to’ the evidence provided by other studies